ea0035p680 | Growth hormone IGF axis basic | ECE2014
Gesing Adam
, Masternak Michal
, Boparai Ravneet
, Lewinski Andrzej
, Karbownik-Lewinska Malgorzata
, Salvatori Roberto
, Bartke Andrzej
Introduction: Long-lived mice with targeted disruption of the GHRH gene (GHRH knockout; GHRHKO) constitute a unique animal model of altered somatotrophic signaling and are characterized by reduced body mass and size, low plasma IGF1 and enhanced insulin sensitivity. These features are also observed in long-lived GH receptor knockout (GHRKO) mice, characterized by increased visceral obesity that usually promotes insulin resistance. GHRKO mice have also increased subcutaneous fa...